Transforming Growth Factor-β 3 (TGF- β3) is a member of the TGF-β3 superfamily and regulates diverse cellular phenotypes. The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. TGF-beta 3 binds to serine-threonine kinase type I and II receptors and activates signal transduction through SMAD2/3 proteins, thus regulating a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, and metabolism (Massagué; McDowell et al.). They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. 

TFG- β3 Human recombinant protein produced in E.coli is a disulfide-linked homo-dimeric, non-glycosylagted, polypeptide chain containing two 113 amino acid chains and having a total molecular mass of 25.8kDa The TGF- β3 is purified by standard chromatographic techniques.

Endotoxin Level

<0.1 EU per µg of protein using LAL analysis.

Formulation

Lyophilized salt free

Purity

95% by SDS PAGE and HPLC analysis.

Amino Acid Sequence

Source

Expressed in Escherichia coli. using MPTxpress platform.

Storage

Store at -20°C to -70°C as supplied, protected from light and moisture; Shelf life: 1 year from the date of receipt.
After reconstitution, the product may be stored for a maximum of two weeks at 2-8°C or may be stored in aliquots at -20°C for a maximum of 6 months.